刘亚西

 

	姓名：刘亚西
	学历：博士	职称：教授、博士生导师
	职务：分子生物学实验室副主任	联系电话：028-86290951
	电子信箱：liuyaxi@sicau.edu.cn	传真：028-82650350

2010年7月获四川农业大学作物遗传育种专业农学博士学位。教授三级岗，博士生导师，四川省学术技术带头人后备人选，四川省海外留学人员，四川省杰出青年基金、自然科学基金重点项目获得者，中国农业生物技术学会植物表型组学专业委员会委员。2008年曾赴澳大利亚联邦科学与工业组织留学，2010年至今在四川农业大学工作。

主持国家自然科学基金青年基金和面上项目各1项、教育部博士点基金1项、四川省教育厅青年基金项目1项、四川省科技厅杰出青年科技人才项目1项、四川省科技厅支撑计划项目1项、四川省人社厅留学人员科技活动择优资助项目1项；主研参加国家十三五“七大作物育种”专项、国家自然科学基金重大研发计划、科技部国际合作专项、“863”计划、“973”计划、国家支撑计划及国家农业科技成果转化资金项目等国家、省部级项目20余项。获四川省科技进步一等奖2项。发表论文100余篇，其中SCI收录80余篇。主研选育小麦新品种11个，获授权国家发明专利10项、计算机软件著作权11项。《Frontiers in Plant Science》Review Editor，《Plant Cell》、《New Phytologist》、《Plant Journal》、《Theretical and Applied Genetics》、《Crop Journal》等杂志审稿人。

---

研究方向：

1、农艺性状的基因发掘、机制解析及育种利用

基于种质资源库的特色地方品种、野生近缘属种、突变体等材料，通过全基因组重测序、基因芯片技术，结合高通量表型组技术，利用全基因关联分析的方法，从全基因组层面发掘分蘖、旗叶、小穗数、粒重、粒型、胚芽鞘等性状的优良新基因。同时，构建双亲分离群体和高密度遗传图谱，解析分蘖、旗叶、穗抽出度、根系、灌浆速率、株高、小穗粒数、粒重等优异性状的遗传基础，并进一步结合分子生物学和多组学技术探索其调控通路，明确控制性状的功能基因，揭示基因作用的分子机制。

此外，以特色地方品种、主栽品种以及其它优良种质资源为材料，利用全基因组选择、基因编辑、合成生物学、计算机模拟等技术，结合独创的温室快速繁育体系，着力构建作物基因设计育种技术体系，进行产量、抗性、品质、株型、育性等育种性状的精准、高效改良，培育适于西南地区的新型农业新品种。

2、多组学大数据智能化分析与利用

主要进行植物多组学大数据解析、生物信息挖掘、智慧农业等相关领域研究，将大数据分析、计算机视觉、机器学习等新一代信息技术与生物农业进行深度融合，重点开展植物多组学大数据挖掘与分析、模型构建、数据库及可视化平台建设等方面工作。

---

部分研究工作：

1、小麦寡分蘖基因发掘

（1）普通小麦新寡分蘖QTL的鉴定与验证

Identification and validation of novel low-tiller number QTL in common wheat. Theoretical and Applied Genetics, 2016, 129 (3): 603-612.

（2）小麦寡分蘖基因(TIN4)的精细定位

Fine mapping of the tiller inhibition gene TIN4 contributing to ideal plant architecture in common wheat. Theoretical and Applied Genetics, 2021, 135(2): 527-535. 

 

2、多组学解析分蘖调控机制

（1）多组学分析寡分蘖Qltn.sicau-2D位点调控机制

Comprehensive transcriptomics, proteomics, and metabolomics analyses of the mechanisms regulating tiller production in low-tillering wheat. Theoretical and applied genetics, 2019, 132(8): 2181-2193.

（2）两对近等基因系中分蘖相关lncRNA鉴定

Identification of lncRNAs involved in wheat tillering development in two pairs of near-isogenic lines. Functional and Integrative Genomics, 2020, 20: 669-679.

 3、穗部性状基因发掘

（1）基于高密度图谱的小穗粒数QTL分析

QTL mapping for grain number per spikelet in wheat using a high-density genetic map. The Crop Journal, 2021, 9: 1108-1114.

（2）小麦籽粒灌浆速率位点的鉴定和验证

Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.). Theoretical and Applied Genetics, 2020, 133: 2377-2385.

（3）大麦粒重关键QTL定位及候选基因预测

Identification of loci and candidate genes controlling kernel weight in barley based on a population for which whole genome assemblies are available for both parents. The Crop Journal, 2020, 9: 854-861.

（4）野生大麦粒长QTL定位与验证

Mapping and validation of major quantitative trait loci for kernel length in wild barley (Hordeum vulgare ssp. spontaneum). BMC Genetics, 2016, 17(1): 130.

 

4、基于组学数据的高通量检测简单重复序列软件开发

SSRMMD: A rapid and accurate algorithm for mining SSR feature loci and candidate polymorphic SSRs based on assembled sequences. Frontiers in Genetics, 2020, 11: 706.

 

---

 

主要论文： 

2022年

1. Kunyu Zhou^#, Yu Lin^#, Xiaojun Jiang, Wanlin Zhou, Fangkun Wu, Caixia Li, Yuming Wei, Yaxi Liu^*. Identification and validation of quantitative trait loci mapping for spike-layer uniformity in wheat. International Journal of Molecular Sciences, 2022, 23: 1502.

2021年

1. Zhiqiang Wang^#, Fangkun Wu^#, Xudong Chen, Wanlin Zhou, Haoran Shi, Yu Lin, Shuai Hou, Shifan Yu, Hong Zhou, Caixia Li, Yaxi Liu^*. Fine mapping of the tiller inhibition gene TIN4 contributing to ideal plant architecture in common wheat. Theoretical and Applied Genetics, 2021, 135(2): 527-535.

2. Yu Lin^#, Kunyu Zhou^#, Haiyan Hu, Xiaojun Jiang, Shifan Yu, Qing Wang, Caixia Li, Jian Ma, Guangdeng Chen, Zisong Yang, Yaxi Liu^*. Multi-locus genome-wide association study of four yield-related traits in Chinese wheat landraces. Frontiers in Plant Science, 2021, 12:665122.

3. Qing Wang^#, Ning Yan^#, Hao Chen, Sirui Li, Haiyan Hu, Yu Lin, Haoran Shi, Kunyu Zhou, Xiaojun Jiang, Shifan Yu, Caixia Li, Guangdeng Chen, Zisong Yang, Yaxi Liu^*, Genome-wide association study of kernel traits in Aegilops tauschii. Frontiers in Genetics, 2021, 12: 1-12.

4. Yu Lin^#, Xiaojun Jiang^#, Haiyan Hu, Kunyu Zhou, Qing Wang, Shifan Yu, Xilan Yang, Zhiqiang Wang, Fangkun Wu, Shihang Liu, Caixia Li, Mei Deng, Jian Ma, Guangdeng Chen, Yuming Wei, Youliang Zheng, Yaxi Liu^*. QTL mapping for grain number per spikelet in wheat using a high-density genetic map. The Crop Journal, 2021, 9: 1108-1114.

2020年

1. Hong Zhou^#, Wei Luo^#, Shang Gao^#, Jian Ma, Meixue Zhou, Yuming Wei, Youliang Zheng, Yaxi Liu^*, Chunji Liu^*. Identification of loci and candidate genes controlling kernel weight in barley based on a population for which whole genome assemblies are available for both parents. The Crop Journal, 2020, 9: 854-861.

2. Zhiqiang Wang, Haiyan Hu, Xiaojun Jiang, Yang Tao, Yu Lin, Fangkun Wu, Shuai Hou, Shihang Liu, Caixia Li, Guangdeng Chen, Yaxi Liu^*. Identification and validation of a novel major quantitative trait locus for plant height in common wheat (Triticum aestivum L.). Frontiers in Genetics, 2020, 11: 1-10.

3. Xiangjian Gou, Haoran Shi, Shifan Yu, Zhiqiang Wang, Caixia Li, Shihang Liu, Jian Ma, Guangdeng Chen, Tao Liu^*, Yaxi Liu^*. SSRMMD: A rapid and accurate algorithm for mining SSR feature loci and candidate polymorphic SSRs based on assembled sequences. Frontiers in Genetics, 2020, 11: 706.

4. Yu Lin, Guangdeng Chen, Haiyan Hu, Xilan Yang, Zhengli Zhang, Xiaojun Jiang, Fangkun Wu, Haoran Shi, Qing Wang, Kunyu Zhou, Caixia Li, Jian Ma, Youliang Zheng, Yuming Wei, Yaxi Liu^*. Phenotypic and genetic variation in phosphorus-deficiency-tolerance traits in Chinese wheat landraces. BMC Plant Biology, 2020, 20: 330.

5. Wanlin Zhou, Haoran Shi, Zhiqiang Wang, Yueting Zhao, Xiangjian Gou, Caixia Li, Guangdeng Chen, Shihang Liu, Mei Deng, Jian Ma, Youliang Zheng, Yuming Wei^*, Yaxi Liu^*. Identification of lncRNAs involved in wheat tillering development in two pairs of near-isogenic lines. Functional and Integrative Genomics, 2020, 20: 669-679.

6. Yu Lin, Xiaojun Jiang, Yang Tao, Xilan Yang, Zhiqiang Wang, Fangkun Wu, Shihang Liu, Caixia Li, Mei Deng, Jian Ma, Guangdeng Chen, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Identification and validation of stable quantitative trait loci for grain filling rate in common wheat (Triticum aestivum L.). Theoretical and Applied Genetics, 2020, 133: 2377-2385.

7. Hong Zhou, Jinlian Luo, Qin Sun, Guangdeng Chen, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Identification and expression profiling of HvMADS57 and HvD14 in a barley tb1 mutant. Journal of Genetics, 2020, 99(1): 1-8.

2019年

1. Yu Lin, Xin Yi, Si Tang, Wei Chen, Fangkun Wu, Xilan Yang, Xiaojun Jiang, Haoran Shi, Jian Ma, Guangdeng Chen, Guoyue Chen, Youliang Zheng, Yuming Wei^*, Yaxi Liu^*. Dissection of phenotypic and genetic variation of drought related traits in diverse Chinese wheat landraces. The Plant Genome, 2019, 12(3): 1-14.

2. Ruixuan Liu, Fangkun Wu, Xin Yi, Yu Lin, Zhiqiang Wang, Shihang Liu, Mei Deng, Jian Ma, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Quantitative trait loci analysis for root traits in synthetic hexaploid wheat under drought stress conditions. Journal of Integrative Agriculture, 2019, 18(0): 1947-1960.

3. Mei Deng^#, Fangkun Wu^#, Wanlin Zhou, Jing Li, Haoran Shi, Zhiqiang Wang, Yu Lin, Xilan Yang, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Mapping of QTL for total spikelet number per spike on chromosome 2D in wheat using a high-density genetic map. Genetics and Molecular Biology, 2019, 42(3): 603-610.

4. Yang Tao, Xin Yi, Yu Lin, Zhiqiang Wang, Fangkun Wu, Xiaojun Jiang, Shihang Liu, Mei Deng, Jian Ma, Guangdeng Chen, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Quantitative trait locus mapping for panicle exsertion length in common wheat using two related recombinant inbred line populations. Euphytica, 2019, 215(6): 104.

5. Zhiqiang Wang, Haoran Shi, Shifan Yu, Wanlin Zhou, Jing Li, Shihang Liu, Mei Deng, Jian Ma, Yuming Wei, Youliang Zheng, Yaxi Liu^*. Comprehensive transcriptomics, proteomics, and metabolomics analyses of the mechanisms regulating tiller production in low-tillering wheat. Theoretical and applied genetics, 2019, 132(8): 2181-2193.

2018年

1. Xilan Yang, Yaxi Liu^*, Fangkun Wu, Xiaojun Jiang, Yu Lin, Zhiqiang Wang, Zhengli Zhang, Jian Ma, Guangdeng Chen, Yuming Wei, Youliang Zheng. Quantitative trait loci analysis of root traits under phosphorus deficiency at the seedling stage in wheat. Genome, 2018, 61: 209-215.

2. Yaxi Liu^#, Yang Tao^#, Zhiqiang Wang, Qiaoling Guo, Fangkun Wu, Xilan Yang, Mei Deng, Jian Ma, Guangdeng Chen, Yuming Wei, Youliang Zheng. Identification of QTL for flag leaf length in common wheat and their pleiotropic effects. Molecular Breeding, 2018, 38(1): 1-11.

2017年

1. Fangkun Wu, Xilan Yang, Zhiqiang Wang, Mei Deng, Jian Ma, Guoyue Chen, Yuming Wei, Yaxi Liu^*. Identification of major quantitative trait loci for root diameter in synthetic hexaploid wheat under phosphorus-deficient conditions. Journal of Applied Genetics, 2017, 58: 437-447.

2. Yu Lin^#, Shihang Liu^#, Yaxi Liu^*, Yujiao Liu^#, Guoyue Chen, Jie Xu, Mei Deng, Qiantao Jiang, Yuming Wei, Youliang Zheng. Genome-wide association study of pre-harvest sprouting resistance in Chinese wheat founder parents. Genetics and Molecular Biology, 2017, 40(3): 620-629.

3. Jian Ma, Puyang Ding, Peng Qin, Yaxi Liu^*, Quan Xie, Guangdeng Chen, Wei Li, Qiantao Jiang, Guoyue Chen, Xiujin Lan, Yuming Wei, Chunji Liu, Youliang Zheng^*. Structure and expression of the TaGW7 in bread wheat (Triticum aestivum L.). Plant Growth Regulation, 2017, 82(2): 281-291.

4. Yaxi Liu^#, Yu Lin^#, Shang Gao, Zhanyi Li, Jian Ma, Mei Deng, Guoyue Chen, Yuming Wei, Youliang Zheng^*. A genome-wide association study of 23 agronomic traits in Chinese wheat landraces. The Plant Journal, 2017, 91: 861–873.

5. Yujiao Liu^#, Yaxi Liu^#, Yong Zhou, Charlene Wight, Zhien Pu, Pengfei Qi, Qiantao Jiang, Mei Deng, Zaoxia Wang, Yuming Wei, Wenguang Cao, Dengcai Liu, Youliang Zheng, Chunji Liu, Judith Frégeau-Reid, Jirui Wang^*. Conferring resistance to pre-harvest sprouting in durum wheat by a QTL identified in Triticum spelta. Euphytica, 2017, 213(1): 19.

2016年

1. Hong Zhou, Shihang Liu, Yujiao Liu, Yaxi Liu^*, Jing You, Mei Deng, Jian Ma, Guangdeng Chen,Yuming Wei, Chunji Liu, Youliang Zheng. Mapping and validation of major quantitative trait loci for kernel length in wild barley (Hordeum vulgare ssp. spontaneum). BMC Genetics, 2016, 17(1): 130.

2. Peng Qin, Yu Lin, Yaodong Hu, Kun Liu, Shuangshuang Mao, Zhanyi Li, Jirui Wang, Yaxi Liu^*, Yuming Wei, Youliang Zheng. Genome-wide association study of drought-related resistance traits in Aegilops tauschii. Genetics and Molecular Biology, 2016, 39, 3, 398-407.

3. Zhiqiang Wang, Yaxi Liu^*, Haoran Shi, Hongjun Mo, Fangkun Wu, Yu Lin, Shang Gao, Jirui Wang, Yuming Wei, Chunji Liu, Youliang Zheng. Identification and validation of novel low-tiller number QTL in common wheat. Theoretical and Applied Genetics, 2016, 129 (3): 603-612.

2015年

1. Lang Wang, Kun Liu, Shuangshuang Mao, Zhanyi Li, Yanli Lu, Jirui Wang, Yaxi Liu^*, Yuming Wei, Youliang Zheng. Large-scale screening for Aegilops tauschii tolerant genotypes to phosphorus deficiency at seedling stage. Euphytica, 2015, 204(3): 571-586.

2. Peng Qin, Lang Wang, Kun Liu, Shuangshuang Mao, Zhanyi Li, Shang Gao, Haoran Shi, Yaxi Liu^*. Genomewide association study of Aegilops tauschii traits under seedling-stage cadmium stress. Crop Journal, 2015, 3(5): 405-415.

3. Yaxi Liu^#, Lang Wang^#, Shuangshuang Mao, Kun Liu, Yanli Lu, Jirui Wang, Yuming Wei, Youliang Zheng^*. Genome-wide association study of 29 morphological traits in Aegilops tauschii. Scientific Reports, 2015, 5: 15562.

4. Yaxi Liu^#, Lang Wang^#, Mei Deng, Zhanyi Li, Yanli Lu, Jirui Wang, Yuming Wei, Youliang Zheng^*. Genome-wide association study of phosphorus-deficiency-tolerance traits in Aegilops tauschii. Theoretical and Applied Genetics, 2015, 128 (11): 2203-2212.

2014年

1. Yaxi Liu, Jirui Wang, Zehou Liu, Yan Wang, Xing Chen, Robert J Henry, Yuming Wei, Eviatar Nevo, Youliang Zheng^*. Adaptive evolution of a‐amylase genes in wild barley (Hordeum spontaneum) on micro and macro scales. Journal of Systematics and Evolution, 2014, 52 (6): 765–778.

2. Jian Yang^#, Yaxi Liu^#, Zhien Pu, Lianquan Zhang, Zhongwei Yuan, Guoyue Chen, Yuming Wei, Youliang Zheng*, Dengcai Liu, Jirui Wang^*. Molecular characterization of high pI a-amylase and its expression QTL analysis in synthetic wheat RILs. Mol Breeding, 2014, 34: 1075–1085.

2013年

1. Zehou Liu, Yong Zhou, Jia Li, Yujiao Liu, Yaxi Liu^*. Molecular characterization of the Amy1 gene in hexaploid wheat. Journal of Plant Sciences, 2013, 8(1): 1.

2. Zehou Liu^#, Yaxi Liu^#, Zhien Pu, Jirui Wang^*, Youliang Zheng, Yanhong Li, Yuming Wei^*. Regulation, evolution, and functionality of flavonoids in cereal crops. Biotechnol Letters, 2013, 35: 1765–1780.

2012年

1. Yaxi Liu, Jirui Wang^*. Molecular Evolution of Exogenous Alpha-amylase Inhibitors in Triticeae - An Update. Functional Plant Science and Biotechnology, 2012, 6(1): 67-74.

2. Yaxi Liu^#, Xiaohuan Sun^#, Biling Xu, Guoyue Chen. Genetic analysis and molecular mapping of low-tillering mutants (cul2.b and lnt1.a) in barley (Hordeum vulgare L.). Journal of Plant Sciences, 2012, 7(3): 105-112.

3. Yaxi Liu, Jun Ma, Wei Yan, Guijun Yan, Meixue Zhou, Yuming Wei, Youliang Zheng, Chunji Liu^*. Different tolerance in bread wheat, durum wheat and barley to fusarium crown rot diaease caused by Fusarium pseudograminearum. Journal of Phytopathology, 2012, 160(5): 412-417.

4. Yaxi Liu, Youliang Zheng, Yuuming Wei, Meixue Zhou, Chunji Liu^*. Genotypic differences to crown rot caused by Fusarium pseudograminearum in barley (Hordeum vulgare L.). Plant Breeding, 2012, 131(6): 728-732.

2010年

1. Yaxi Liu, Xueming Yang, Jian. Ma, Yuuming Wei, Youliang Zheng, Hongxiang Ma, Jingbao Yao, Guijun Yan, Yougan Wang, John Manners, and Chunji Liu^*. Plant height affects Fusarium crown rot severity in wheat. Pytopathology, 2010, 100(8): 1276-1281.