陈健

姓 名：陈健

学 历：博士

职 称：教授，博士生导师

邮 箱：jian.chen@sicau.edu.cn

个人简介：

ORCID https://orcid.org/0000-0001-8670-6984

Google Scholar https://scholar.google.com/citations?user=n2bnwZAAAAAJ&hl=en

ResearchGate https://www.researchgate.net/profile/Jian-Chen-198?ev=hdr_xprf

2017年于澳大利亚国立大学（Australian National University, ANU）与澳大利亚联邦科学与工业研究组织（CSIRO）联合培养获得植物病理学博士学位，随后在CSIRO从事博士后研究工作。2025年入选国家海外高层次青年人才。长期围绕小麦重大病害抗病机制开展研究，在植物免疫受体识别病原菌效应蛋白、病原菌无毒基因鉴定、植物免疫信号激活机制以及抗病基因工程化设计等领域积累了丰富经验。

近年来聚焦小麦茎秆锈病等全球重要病害，系统开展病原菌效应蛋白鉴定、抗病基因功能解析、植物免疫受体结构生物学及工程化设计研究。以第一作者或共同第一作者身份在Science、Nature Plants、New Phytologist、The Plant Journal和iScience等国际主流期刊发表论文20余篇。作为发明人参与国际PCT专利申请2项，并作为主要发明人开展植物免疫受体工程化设计相关专利布局，为新型广谱抗病基因创制提供理论与技术基础。

课题组将致力于解析植物识别病原菌的分子机制，并利用结构生物学、人工智能和蛋白工程技术设计新型抗病基因，为培育广谱、持久抗病的小麦新品种提供理论基础和技术支撑。

主要研究领域：

1. 植物免疫受体识别病原菌效应蛋白的分子机制

2. 成株期抗病性（APR）的作用机制及其与植物免疫系统的协同调控

3. 植物免疫受体工程化设计

学术论文代表作：

Chen J., Hands, P., Patel, M., Yang, L., Zhong, C., Smith, N., Luo, M., and Ayliffe, M. (2026). Trichome formation in Nicotiana benthamiana is induced by certain Agrobacterium tumefaciens strains. Frontiers in Plant Science Volume 17 - 202610.3389/fpls.2026.1762747.

Chen R^*, Chen J^*, Powell O R^*, Outram M A^*, Arndell T, Gajendiran K, Wang Y L, Lubega J, Xu Y, Ayliffe M A,… Dodds P N, and Wulff B B H (2025). A wheat tandem kinase activates an NLR to trigger immunity. Science 387, 1402-1408. 10.1126/science.adp5034. *Equal contribution

Outram M A^*, Chen J^*, Broderick S, Li Z, Aditya S, Tasneem N, Arndell T, Blundell C, Ericsson D J, Figueroa M, Sperschneider J, Dodds P N, and Williams S J (2024). AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition. New Phytologist 243, 314-329. *Equal contribution

Arndell T, Chen J, Sperschneider J, Upadhyaya N M, Blundell C, Niesner N, Outram M A, Wang A H, Swain S, Luo M, Ayliffe M A, Figueroa M, Vanhercke T, and Dodds P N (2024). Pooled effector library screening in protoplasts rapidly identifies novel genes. Nature Plants 10.

Chen J, Zhang X, Bernoux M, Rathjen J P, and Dodds P N (2024). Plant Toll/interleukin-1 receptor/resistance protein domains physically associate with enhanced disease susceptibility1 family proteins in immune signaling. Iscience 27. ARTN 108817

Chen J, Luo M, Hands P, Rolland V, Zhang J P, Li Z, Outram M, Dodds P, and Ayliffe M (2023). A split GAL4 RUBY assay for visual in planta detection of protein‐protein interactions. Plant Journal 114, 1209-1226.

Chen J, Zhang X, Rathjen J P, and Dodds P N (2022). Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling. Essays in Biochemistry 66, 471-483.

Ortiz D*, Chen J*, Outram M A*, Saur I M L, Upadhyaya N M, Mago R, Ericsson D J, Cesari S, Chen C, Williams S J, and Dodds P N (2022). The stem rust effector protein AvrSr50 escapes Sr50 recognition by a substitution in a single surface-exposed residue. New Phytologist 234, 592-606.*Equal contribution

Horsefield S, Burdett H, Zhang X, Manik M K, Shi Y, Chen J, Qi T, Gilley J, Lai J S, Rank M X, Casey L W, Gu W, Ericsson D J, Foley G, Hughes R O, Bosanac T, von Itzstein M, Rathjen J P, Nanson J D, Boden M, Dry I B, Williams S J, Staskawicz B J, Coleman M P, Ve T, Dodds P N, and Kobe B (2019). NAD⁺ cleavage activity by animal and plant TIR domains in cell death pathways. Science 365, 793-799.