魏育明

时间: 2013-07-01 点击次数:



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姓 名:魏育明
学 历:博士 职 称:教授,博士导师
职 务:所长 电 话:86-28-86290909
电 箱:ymwei@sicau.edu.cn 传 真:86-28-82650350



个人简介:

       四川农业大学1990级学士、1994级硕士、1997级博士,20007月获农学博士学位。2003年全国优秀百篇博士学位论文获得者,2005年入选教育部新世纪优秀人才支持计划并破格晋升为教授,20075月获四川青年五四奖章,2010年入选四川省学术和技术带头人,2018年国务院政府特殊津贴专家。20037月至20047月作为国家公派访问学者赴加拿大留学一年。

先后主持国家自然科学基金、863计划、国家国际合作专项、教育部和四川省科技厅和教育厅科研项目30余项。获四川省科技进步奖一等奖3项(排名第二、第三和第四)、三等奖3项(排名第一、第三和第五)。获国家授权发明专利22项,在SCI收录期刊上发表学术论文226篇。2003年开始招收硕士研究生、2007年开始招收博士研究生。


主要研究领域:小麦遗传与育种

博硕士招生专业:作物遗传育种




主要研究方向:

1. 小麦重要性状基因的分子标记及育种利用

小麦产量、品质和抗性等性状往往是多基因控制的复杂性状,也是小麦遗传改良的重要目标性状。课题组对高产、优质、抗病或抗逆等优异基因的遗传材料进行筛选鉴定,构建遗传分析群体,对这些重要性状基因进行分子标记,并将获得的与重要性状基因连锁的分子标记应用于小麦分子标记辅助育种,进行小麦新材料创制与新品种选育。本研究受到四川省重大科技专项和四川省农业厅产业技术体系麦类作物创新团队项目资助。

2.
利用缺失突变体研究小麦高分子量谷蛋白表达调控相关转录因子

高分子量谷蛋白(HMW-GS)决定小麦面团的弹性,对加工品质起重要作用。小麦品种HMW-GS组成稳定,但其含量易受环境影响,这表明有上游调控因子影响HMW-GS表达。我们创制了小麦品种蜀麦482的整套HMW-GS缺失系;多年多点实验证明在不同生态条件下蜀麦482的蛋白质含量、面筋含量、沉降值、HMW-GS含量等存在显著差异。本项目拟在加工品质差异极显著的生态点种植蜀麦482及其HMW-GS缺失突变体,利用表达谱分析生态点间和材料间的差异表达基因,筛选调节HMW-GS表达的候选转录因子,然后利用酵母杂交、RT-Q-PCR、凝胶阻滞实验、染色体免疫共沉淀、转基因等经典方法鉴定转录因子并验证其功能。在此基础上分析转录因子通过调控HMW-GS表达影响小麦加工品质的分子机理,为小麦加工品质的遗传改良提供关键基因。本研究受国家自然科学基金资助。

3. 点突变导致小麦Dy10亚基翻译后剪切的分子机制及其加工品质效应

高分子量谷蛋白(HMW-GS)决定小麦面团的弹性,对加工品质起重要作用。Dy10亚基与面筋强度密切相关,是公认的优质亚基。我们利用化学诱变创制了一份蜀麦482 Dy10亚基突变体,发现其Dy10亚基C-末端非重复区一个碱基的变异导致部分Dy10蛋白在合成过程中被酶切,从而形成一种新型Dy10亚基。本项目拟在前期工作基础上,综合利用酵母杂交、GST pull-down和质谱检测、体外表达纯化及蛋白复性技术、亚细胞共定位技术、转基因、双分子荧光互补实验等技术,鉴定出负责翻译后切割突变体Dy10亚基的酶及其基因,明确其切割突变体Dy10亚基的分子机制;通过构建比较野生型和突变体的加工品质参数,评价突变体Dy10亚基的加工品质效应。在此基础上,明确点突变导致小麦高分子量谷蛋白Dy10亚基翻译后剪切的分子机制及其加工品质效应。本研究受国家自然科学基金资助。



近期论文:

1. Ma J*, Tu Y, Zhu J, Luo W, Liu H, Li C, Li S, Liu J, Ding P, Habib A, Mu Y, Tang H, Liu Y, Jiang Q, Chen G, Wang J, Li W, Pu Z, Zheng Y, Wei Y, Kang H, Chen G, Lan X. Flag leaf size and posture of bread wheat: genetic dissection, QTL validation and their relationships with yield-related traits. Theoretical and Applied Genetics, 2020, 133: 297-315

2. Yang Q, Zhong X, Li Q, Lan J, Tang H, Qi P, Ma J, Wang J, Chen G, Pu Z, Li L, Lan X, Deng M, Harwood W, Li Z, Wei YM, Zheng YL, Jiang Q*. Mutation of the D-hordein gene by RNA-guided Cas9 targeted editing reducing the grain size and changing grain compositions in barley, Food Chemistry, 2020,125892

3. Li T, Ma J, Zou Y, Chen G, Ding P-Y, Zhang H, Yang C-C, Mu Y, Tang H, Liu Y, Jiang Q, Chen G-Y, Qi P-F, Wei Y-M, Zheng Y, Lan X-J. Quantitative trait loci for seeding root traits and the relationships between root and agronomic traits in common wheat. Genome, 2020, 63: 27-36

4. Jiang Y, Chen Q, Wang Y, Guo Z, Xu B, Zhu J, Zhang Y, Gong X, Luo C, Wu W, Liu C, Kong L, Deng M, Jiang Q, Lan X, Wang J, Chen G, Zheng Y*, Wei YM, Qi P*. Re-acquisition of the brittle rachis trait via a transposon insertion in domestication gene Q during wheat de-domestication. New Phytologist, 2019, 224: 961-973

5. Lin Y, Yi X, Tang S, Chen W, Wu FK, Yang XL, Jiang XJ, Shi HR, Ma J, Chen GD, Chen GY, Zheng YL, Wei YM*, Liu YX*. Dissection of Phenotypic and Genetic Variation of Drought Related Traits in Diverse Chinese Wheat Landraces. The Plant Genome, 2019, 12 (3):1-14.

6. Ma J,*, Ding P, Liu J, Li T, Zou Y, Habib A, Mu Y, Tang H, Jiang Q, Liu Y, Chen G, Wang J, Deng M, Qi P, Li W, Pu Z, Zheng Y, Wei Y, Lan X*. Identification and validation of a major and stably expressed QTL for spikelet number per spike in bread wheat. Theoretical and Applied Genetics , 2019, 132: 3155–3167

7. Luo M, Ding JJ, Li Y, Tang HP, Qi PF, Ma J, Wang JR, Chen GY, Pu ZE, Li W, Li ZY, W Harwood, Lan XJ, Deng M, Lu ZX, Wei YM, Zheng YL, Jiang QT*. A single-base change at a splice site in Wx-A1 caused incorrect RNA splicing and gene inactivation in a wheat EMS mutant line. Theoretical and Applied Genetics, 2019, 132: 2097-2109

8. Ma J, Qin N, Cai B, Chen G, Ding P, Zhang H, Yang C, Huang L, Mu Y, Tang H, Liu Y, Wang J, Qi P, Jiang Q, Zheng YL, Liu C, Lan X, Wei YM*. Identification and validation of a novel major QTL for all-stage stripe rust resistance on 1BL in the winter wheat line 20828. Theoretical and Applied Genetics, 2019, 132: 1363-1373

9. Luo M, Ding JJ, Li Y, Tang HP, Qi PF, Ma J, Wang JR, Chen GY, Pu ZE, Li W, Li ZY, Harwood W, Lan XJ, Deng M, Lu ZX, Wei YM, Zheng YL, Jiang QT*. A single-base change at a splice site in Wx-A1 caused incorrect RNA splicing and gene inactivation in a wheat EMS mutant line. Theoretical and Applied Genetics, 2019, 132: 2097–2109

10. Jiang YF, Habib A, Zheng Z, Zhou MX, Wei YM, Zheng YL, Liu CJ*. Development of tightly linked markers and identification of candidate genes for Fusarium crown rot resistance in barley by exploiting a near isogenic line derived population. Theoretical and Applied Genetics, 2019, 132: 217–225

11. Hao M, Zhang LQ, Zhao LB, Dai SF, Li AL, Yang WY, Xie DE, Li QC, Ning SZ, Yan ZH, Wu BH, Lan XJ, Yuan ZW, Huang L, Wang JR, Zheng K, Chen WS, Yu M, Chen XJ, Chen MP, Wei YM, Zhang HG, Kishii M , Hawkesford MJ, Mao L, Zheng YL, Liu DC*. A breeding strategy targeting the secondary gene pool of bread wheat: introgression from a synthetic hexaploid wheat. Theoretical and Applied Genetics, 2019, 132: 2285-2294

12. Wang ZQ, Shi HR, Yu SF, Zhou WL, Li J, Liu SH, Deng M, Ma J, Wei YM, Zheng YL, Liu YX*. Comprehensive transcriptomics, proteomics, and metabolomics analyses of the mechanisms regulating tiller production in low-tillering wheat. Theoretical and Applied Genetics, 2019, 132(8):2181-2193

13. Zhang YZ, Chen Q, Liu CH, Lei L, Li Y, Zhao K, Wei MQ, Guo ZR, Wang Y, Xu BJ, Jiang YF, Kong L, Liu YL, Lan XJ, Jiang QT, Ma J, Wang JR, Chen GY, Wei YM*, Zheng YL, Qi PF*. Fusarium graminearum FgCWM1 encodes a cell wall mannoprotein conferring sensitivity to salicylic acid and virulence to wheat. Toxins, 2019, 11: 628

14. Ye XL, Li J, Cheng YK, Yao FJ, Long L, Yu C, Wang YQ, Wu Y, Li J, Wang JR, Jiang QT, Li W, Ma J, Wei YM, Zheng YL, Chen GY*. Genome-wide association study of resistance to stripe rust (Puccinia striiformis f. sp. tritici) in Sichuan wheat. BMC Plant Biology, 2019, 19:147

15. Ye XL, Li J, Cheng YK, Yao FJ, Long L, Wang YQ, Wu Y, Li J, Wang JR, Jiang QT, Kang HY, Li W, Qi PF, Lan XJ, Ma J, Liu YX, Jiang YF, Wei YM, Chen XM, Liu, CJ, Zheng YL*, Chen GY*. Genome-wide association study reveals new loci for yield-related traits in Sichuan wheat germplasm under stripe rust stress. BMC Genomics, 2019, 20: 640

16. Qi PF*, Jiang YF, Guo ZR, Chen Q, Ouellet T, Zong LJ, Wei ZZ, Wang Y, Zhang YZ, Xu BJ, Kong L, Deng M, Wang JR, Chen GY, Jiang QT, Lan XJ, Li W, Wei YM, Zheng YL. Transcriptional reference map of hormone responses in wheat spikes. BMC Genomics, 2019, 20: 390

17. Fangjie Yao, Xuemei Zhang, Xueling Ye,Jian Li, Li Long, Can Yu, Jing Li, Yuqi Wang, Yu Wu, Jirui Wang, Qiantao Jiang, Wei Li, Jian Ma, Yuming Wei, Youliang Zheng, Guoyue Chen*. Characterization of molecular diversity and genome-wide association study of stripe rust resistance at the adult plant stage in Northern Chinese wheat landraces. BMC Genetics, 2019, 20:38

18. Ma J*, Zhang H, Li S, Zou Y, Li T, Liu J, Ding P, Mu Y, Tang H, Deng M, Liu Y, Jiang Q, Chen G, Kang H, Li W, Pu Z, Wei YM, Zheng Y, Lan X*. Identification of quantitative trait loci for kernel traits in a wheat cultivar Chuannong16. BMC Genetics, 2019, 20: 77

19. Qi PF, Zhang YZ, Liu CH, Chen Q, Guo ZR, Wang Y, Xu BJ, Jiang YF, Zheng T, Gong X, Luo CH, Wu W, Kong L, Deng M, Ma J, Lan XJ, Jiang QT, Wei YM*, Wang JR, Zheng YL. Functional Analysis of FgNahG Clarifies the Contribution of Salicylic Acid to Wheat (Triticum aestivum) Resistance against Fusarium Head Blight. Toxins, 2019: 11, 59

20. Liu H, Ma J*, Tu Y, Zhu J, Ding P, Liu J, Li T, Zou Y, Habib A, Mu Y, Tang H, Jiang QT, Liu Y, Chen G, Zheng YL, Wei YM, Lan XJ. Several stably expressed QTL for spike density of common wheat (Triticum aestivum) in multiple environments. Plant Breeding, 2019, 00: 1-11

21. Zhou Y, Chen ZX, Cheng MP, Chen J, Zhu TT, Wang R, Liu YX, Qi PF, Chen GY, Jiang QT, Wei YM, Luo MC, Nevo E, Allaby RG, Liu DC, Wang JR*, Dvorák J*, Zheng YL*. Uncovering the Dispersion History, Adaptive Evolution and Selection of Wheat in China. Plant Biotechnology Journal, 2018, 16: 280-291







 

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